Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation
Heat shock proteins (Hsps) are highly conserved molecular chaperones that are
ubiquitously expressed in all species to aid the solubilization of misfolded proteins, protein …
ubiquitously expressed in all species to aid the solubilization of misfolded proteins, protein …
Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial …
Host-pathogen interactions play an important role in defining the outcome of a disease.
Recent studies have shown bacterial quorum sensing molecules (QSM) can interact with …
Recent studies have shown bacterial quorum sensing molecules (QSM) can interact with …
Bitter taste receptors: Extraoral roles in pathophysiology
Over the past decade tremendous progress has been made in understanding the functional
role of bitter taste receptors (T2Rs) and bitter taste perception. This review will cover the …
role of bitter taste receptors (T2Rs) and bitter taste perception. This review will cover the …
Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues
The mouse bitter taste receptors Tas2r143, Tas2r135, and Tas2r126 are encoded by genes
that cluster on chromosome 6 and have been suggested to be expressed under common …
that cluster on chromosome 6 and have been suggested to be expressed under common …
Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection
Bitter receptors function primarily in sensing taste, but may also have other functions, such
as detecting pathogenic organisms due to their agile response to foreign objects. The …
as detecting pathogenic organisms due to their agile response to foreign objects. The …
Chemosensors in the nose: guardians of the airways
The G-protein-coupled receptor molecules and downstream effectors that are used by taste
buds to detect sweet, bitter, and savory tastes are also utilized by chemoresponsive cells of …
buds to detect sweet, bitter, and savory tastes are also utilized by chemoresponsive cells of …
Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients
Background Bitter and sweet taste receptors are present in the human upper airway, where
they have roles in innate immunity. Previous studies have shown that 1 of the 25 bitter …
they have roles in innate immunity. Previous studies have shown that 1 of the 25 bitter …
Role of taste receptors as sentinels of innate immunity in the upper airway
Evidence is emerging that shows taste receptors serve functions outside of taste sensation
of the tongue. Taste receptors have been found in tissue across the human body, including …
of the tongue. Taste receptors have been found in tissue across the human body, including …
Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
M Tizzano, BD Gulbransen… - Proceedings of the …, 2010 - National Acad Sciences
The upper respiratory tract is continually assaulted with harmful dusts and xenobiotics
carried on the incoming airstream. Detection of such irritants by the trigeminal nerve evokes …
carried on the incoming airstream. Detection of such irritants by the trigeminal nerve evokes …
Genotype-specific regulation of oral innate immunity by T2R38 taste receptor
S Gil, S Coldwell, JL Drury, F Arroyo, T Phi… - Molecular …, 2015 - Elsevier
The bitter taste receptor T2R38 has been shown to regulate mucosal innate immune
responses in the upper airway epithelium. Furthermore, SNPs in T2R38 influence the …
responses in the upper airway epithelium. Furthermore, SNPs in T2R38 influence the …