Bitter and sweet receptors (T2Rs and T1Rs) are expressed in many extra-oral tissues
including upper and lower airways. To investigate if bitter tastants and artificial sweeteners …

Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has
primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and …

Asthma is characterized by airway inflammation, mucus secretion, remodeling and
hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of …

The sense of taste determines the choice of nutrients and food intake and, consequently,
influences feeding behaviors. The taste papillae are primarily composed of three types of …

Bitter taste receptors (TAS2Rs) have recently been found to be expressed on human airway
smooth muscle (HASM), and their activation results in marked relaxation. These agents have …

Heat shock proteins (HSPs), produced in response to stress, are suppressive in disease
models. We previously showed that Mycobacterium leprae HSP65 prevented development …

Bitter taste receptors (TAS2Rs) are G-protein-coupled receptors now recognized to be
expressed on extraoral cells, including airway smooth muscle (ASM) where they evoke …

Bronchodilators are a standard medicine for treating airway obstructive diseases, and β2
adrenergic receptor agonists have been the most commonly used bronchodilators since …

Bitter (T2R) and sweet taste (T1R) receptors have emerged as regulators of upper airway
immune responses. Genetic variation of these taste receptors additionally confers …

Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial
pathogenesis. Recently, the bitter taste receptor TAS2R38 has been described to play a role …