Background Though, first identified in the gastrointestinal tract, bitter taste receptors are now
believed to be ubiquitously expressed in several regions of the body, including the …

Despite the present treatments for asthma (β2-adrenoceptor agonists, glucocorticoids,
leukotriene receptor antagonists), many subjects with asthma have difficulty controlling it …

Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …

The gustatory system detects tastants and transmits signals to the brain regarding ingested
substances and nutrients. Although tastant receptors and taste signaling pathways have …

Background Solitary chemosensory cells (SCCs) are specialized cells in the respiratory
epithelium that respond to noxious chemicals including bacterial signaling molecules. SCCs …

Neutrophils play an important role in the initiation of innate immunity against infection and
injury. Although many different types of G-protein coupled receptors are functionally …

Inflammatory cytokines are important regulators of metabolism and food intake. Over
production of inflammatory cytokines during bacterial and viral infections leads to anorexia …

Bitter taste receptors (TAS2Rs) were shown to be expressed in human airway smooth
muscle (ASM). They couple to specialized [Ca2+] i release, leading to membrane …

Background T2R bitter taste receptors play a crucial role in sinonasal innate immunity by
upregulating mucociliary clearance and nitric oxide (NO) production in response to bitter …

Type-2 bitter taste receptors (Tas2Rs) are a large family of G protein-coupled receptors that
are expressed in the oral cavity and serve to detect substances with bitter tastes in foods and …