Taste and smell receptor expression has been traditionally limited to the tongue and nose.
We have identified bitter taste receptors (TAS2Rs) and olfactory receptors (ORs) on human …

Background Sinonasal biofilms have been demonstrated in specimens collected from
chronic rhinosinusitis (CRS) patients. Mounting evidence suggests that biofilms contribute to …

Asthma is a complex chronic disorder of the airways, affecting immune and structural cells
and inducing both protein and tissue remodeling. Heat shock proteins 70 kDa (HSP70s) are …

Taste receptors were named for their originally-identified expression on the tongue and role
in the sensation of taste (gustation). They are now known to be involved in many …

For protection from inhaled pathogens many strategies have evolved in the airways such as
mucociliary clearance and cough. We have previously shown that protective respiratory …

Abstract Purpose of Review From single cells to entire organisms, biological entities are in
constant communication with their surroundings, deciding what to 'allow'in, and what to …

Airway remodeling is a hallmark feature of asthma and chronic obstructive pulmonary
disease. Clinical studies and animal models have demonstrated increased airway smooth …

Background Chemical irritation of airway mucosa elicits a variety of reflex responses such as
coughing, apnea, and laryngeal closure. Inhaled irritants can activate either chemosensitive …

T1Rs are expressed in solitary chemosensory cells of the upper airway where they detect
apical glucose levels and repress bitter taste receptor Ca2+ signaling pathways. Microbial …

Some bitter taste receptors (TAS2R gene products) are expressed in the human sinonasal
cavity and may function to detect airborne irritants. The expression of all 25 human bitter …