The growing awareness of the critical role played by the innate and adaptive immune
systems in the mechanisms underlying chronic pain has prompted further research …

It is widely accepted that communication between the nervous and immune systems is
involved in the development of chronic pain. At each level of the nervous system, immune …

Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …

Pain is an unpleasant sensation associated with injury, inflammation, and infection. It has
been demonstrated that communication between immune cells and neurons plays a vital …

Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a
tremendous impact on the physiological functions of the body, manifesting itself as a …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis
(OA) and implant aseptic loosening (AL), is a highly debilitating symptom that impacts …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Chronic pain remains a public health problem and contributes to the ongoing opioid
epidemic. Current pain management therapies still leave many patients with poorly …

Chronic pain is a debilitating condition and, in most cases, difficult to treat. A prominent
example of this is neuropathic pain. Understanding pathophysiological mechanisms of pain …