Chronic pain is a debilitating condition that affects up to 20-25% of the population
worldwide. Given its complexity, it is notoriously difficult to treat. The rise in the opioid …

Chronic pain is a debilitating condition that affects up to 20-25% of the population
worldwide. Given its complexity, it is notoriously difficult to treat. The rise in the opioid …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Spinal dorsal horn disinhibition has been implicated in neuropathic pain, a debilitating
condition resulting from damage to the nervous system. Loss of dorsal horn inhibitory …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Microglia are the highly dynamic immune-related glial cells, also known as the specialized
tissue macrophage of the CNS [1–3]. Under physiological conditions, these cells are …

Chronic pain is a common and often debilitating problem that affects 100 million Americans.
A better understanding of pain's molecular mechanisms is necessary for developing safe …

Neuropathic pain is a debilitating condition resulting from damage to the nervous system.
Imbalance of spinal excitation and inhibition has been proposed to contribute to neuropathic …