The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …

MiRNAs are a conserved class of non-coding RNAs that negatively regulate gene
expression post-transcriptionally. Although their biological roles are largely unknown …

Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …

• Introduction‐Brief history, biogenesis and the regulated mechanism of miRNAs• Roles of
miRNAs in human disease and miRNAs as a novel biomarker for cancer and disease …

The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

Within the last 15 years, microRNAs (miRNAs) have emerged as powerful regulators of gene
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …

MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

MicroRNA molecules (miRNAs) are naturally occurring triggers of the RNA-interference
pathway. The first identified miRNA, lin-4, was discovered in Caenorhabditis elegans> 20 …

The discovery of miRNAs as important regulatory agents for gene expression has expanded
the therapeutic opportunities for oligonucleotides. In contrast to siRNA, miRNA-targeted …