Oral exposure of sulpiride promotes the proliferation of Brown‑Norway rat prostates

C Zheng, Y Luo, Y Chen, D Chen… - Experimental and …, 2020 - spandidos-publications.com
The aim of the present study was to establish an animal model of prostatic hyperplasia to
explore the mechanisms of this disease. Sulpiride, a specific type 2 dopamine receptor …

Treatment with WS® 1541 leads to a reduction of gene expression for proinflammatory mediators and growth factors in the prostate of rats with sulipride-induced BPH

S Kraft, M Nöldner, U Scheyhing, K Rollet… - Planta …, 2016 - thieme-connect.com
WS® 1541, a phytopharmaceutical product based on a combination of extracts from fruits of
Sabal serrulata (WS® 1473) and roots from Urtica dioica (WS® 1031), is used to treat …

Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats

P Sánchez, JM Torres, P Vílchez, RG Del Moral… - Iubmb …, 2008 - Wiley Online Library
Prolactin (PRL) is implicated in prostate growth and in the development and regulation of
benign prostatic hypertrophy (BPH) and prostate cancer (PCa). PRL may exert its effects on …

Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats

RT Atawia, MG Tadros, AE Khalifa, HA Mosli… - Toxicology letters, 2013 - Elsevier
Androgen and estrogen play an important role in the pathogenesis of benign prostatic
hyperplasia (BPH). Estrogen exerts its action through two distinct estrogen receptors (ERs) …

Safety and efficacy of a novel Prunus domestica extract (Sitoprin, CR002) on testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats

A Swaroop, M Bagchi, P Kumar… - Toxicology …, 2015 - Taylor & Francis
The efficacy of a novel Prunus domestica bark extract (Sitoprin, CR002) was investigated on
testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) in male Wistar …

Modulatory effect of silymarin on apoptosis in testosterone-induced benign prostatic hyperplasia in rats

NE El-Ashmawy, EG Khedr, HA El-Bahrawy… - Pathology & Oncology …, 2020 - Springer
Benign prostatic hyperplasia (BPH) is considered a normal part of the aging process in men,
and is characterized by an imbalance between cell proliferation and apoptosis. Our study …

The anti‐oestrogen fulvestrant (ICI 182,780) reduces the androgen receptor expression, ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate

SAF Fernandes, GRO Gomes, ER Siu… - … journal of andrology, 2011 - Wiley Online Library
This study proposed to investigate further the role of oestrogens during pubertal growth of rat
ventral prostate, by analysing the effect of anti‐oestrogen fulvestrant (ICI 182,780) on the …

Resveratrol attenuates the proliferation of prostatic stromal cells in benign prostatic hyperplasia by regulating cell cycle progression, apoptosis, signaling pathways …

J Jang, J Song, J Lee, SK Moon, B Moon - International Journal of …, 2021 - mdpi.com
Resveratrol can inhibit cell proliferation and metastasis and induce apoptosis. However, the
mechanisms of action through which resveratrol inhibits the abnormal proliferation of …

Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB

RT Atawia, HH Mosli, MG Tadros, AE Khalifa… - Naunyn-Schmiedeberg's …, 2014 - Springer
The current study aimed to investigate the potential role of the anti-inflammatory effects of
silymarin (SIL) in inhibiting experimentally induced benign prostatic hyperplasia (BPH) in …

Simvastatin ameliorates testosterone-induced prostatic hyperplasia in rats via modulating IGF-1/PI3K/AKT/FOXO signaling

NH El-Shafei, MA Zaafan, EA Kandil… - European journal of …, 2023 - Elsevier
Benign prostatic hyperplasia (BPH) is characterized by non-malignant enlargement of
prostate cells causing many lower urinary tract symptoms. BPH pathogenesis includes …