From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis

G Pérez-Machado, E Berenguer-Pascual… - Bone, 2020 - Elsevier
Scoliosis is defined as the three-dimensional (3D) structural deformity of the spine with a
radiological lateral Cobb angle (a measure of spinal curvature) of≥ 10° that can be caused …

Idiopathic scoliosis: etiological concepts and hypotheses

R Dayer, T Haumont, W Belaieff… - Journal of children's …, 2013 - journals.sagepub.com
Scoliosis is diagnosed as idiopathic in 70% of structural deformities affecting the spine in
children and adolescents, probably reflecting our current misunderstanding of this disease …

Adolescent idiopathic scoliosis

JC Cheng, RM Castelein, WC Chu… - Nature reviews disease …, 2015 - nature.com
Adolescent idiopathic scoliosis (AIS) is the most common form of structural spinal deformities
that have a radiological lateral Cobb angle—a measure of spinal curvature—of≥ 10. AIS …

Adolescent idiopathic scoliosis: a review of aetiological theories of a multifactorial disease

S Marya, AD Tambe, PA Millner… - The Bone & Joint …, 2022 - boneandjoint.org.uk
Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …

Epigenetic and genetic factors related to curve progression in adolescent idiopathic scoliosis: a systematic scoping review of the current literature

C Faldini, M Manzetti, S Neri, F Barile, G Viroli… - International journal of …, 2022 - mdpi.com
Adolescent idiopathic scoliosis (AIS) is a progressive deformity of the spine. Scoliotic curves
progress until skeletal maturity leading, in rare cases, to a severe deformity. While the Cobb …

Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review

S De Salvatore, L Ruzzini, UG Longo, M Marino… - BMC Medical …, 2022 - Springer
Abstract Background Idiopathic Scoliosis (IS) is the most common spinal deformity in
adolescents, accounting for 80% of all spinal deformities. However, the etiology remains …

Whither the etiopathogenesis (and scoliogeny) of adolescent idiopathic scoliosis? Incorporating presentations on scoliogeny at the 2012 IRSSD and SRS meetings

RG Burwell, PH Dangerfield, A Moulton, TB Grivas… - Scoliosis, 2013 - Springer
This paper aims to integrate into current understanding of AIS causation, etiopathogenetic
information presented at two Meetings during 2012 namely, the International Research …

Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood

CA Wise, X Gao, S Shoemaker, D Gordon… - Current …, 2008 - ingentaconnect.com
Idiopathic scoliosis (AIS) is the most common pediatric spinal deformity, affecting∼ 3% of
children worldwide. AIS significantly impacts national health in the US alone, creating …

Adolescent idiopathic scoliosis: evidence for intrinsic factors driving aetiology and progression

MMP Newton Ede, SW Jones - International orthopaedics, 2016 - Springer
Adolescent idiopathic scoliosis (AIS) is now considered to be a multifactorial heterogeneous
disease, with recent genomic studies supporting the role of intrinsic factors in contributing to …

Recent advances in the aetiology of adolescent idiopathic scoliosis

KMC Cheung, T Wang, GX Qiu, KDK Luk - International orthopaedics, 2008 - Springer
The aetiology of adolescent idiopathic scoliosis (AIS) is still unknown despite many years of
research effort. Theories on AIS's aetiology have included mechanical, hormonal, metabolic …