The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

The anorexigenic hormone leptin plays an important role in the control of food intake and
feeding-related behavior, for an important part through its action in the hypothalamus. The …

Eating disorders are a group of disease states including anorexia nervosa, bulimia nervosa
and binge eating on one end as well as episodic or chronic overeating resulting in obesity at …

Since its discovery, leptin (a 167‐amino acid product of the OB gene) has quickly moved to
the forefront as an important hormone for regulation of energy balance. It closes a feedback …

The discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent …

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and
secreted by white adipose tissue. Since its discovery, leptin has been found to have …

The discovery of the adipocyte-produced hormone leptin has greatly changed the field of
obesity research and our understanding of energy homeostasis. It is now accepted that …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …

Leptin affects feeding, metabolism, and neuroendocrine status. It is now clearly established
that the hypothalamus coordinates these responses, though the specific brain regions …