Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome
D Hu, H Barajas-Martínez, R Pfeiffer, F Dezi… - Journal of the American …, 2014 - jacc.org
Background: BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …
probands have genetically identified pathogenic variants. Recent evidence has implicated …
Brugada syndrome
B Benito, R Brugada, J Brugada, P Brugada - Progress in cardiovascular …, 2008 - Elsevier
Since its first description in 1992 as a new clinical entity, the Brugada syndrome has
aroused great interest among physicians and basic scientists. Two consensus conferences …
aroused great interest among physicians and basic scientists. Two consensus conferences …
Brugada syndrome: clinical, genetic, molecular, cellular and ionic aspects
C Antzelevitch - Expert review of cardiovascular therapy, 2003 - Taylor & Francis
Brugada syndrome, first described as a new clinical entity by Pedro and Josep Brugada in
1992, has attracted great interest because of its high prevalence in many regions of the …
1992, has attracted great interest because of its high prevalence in many regions of the …
Commentary on the Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome
P Brugada - Circulation: Arrhythmia and Electrophysiology, 2010 - Am Heart Assoc
Eighteen years2 after the initial description of 8 patients with what has become known as
Brugada syndrome, this disease has changed from an ECG curiosity to a diagnosis to be …
Brugada syndrome, this disease has changed from an ECG curiosity to a diagnosis to be …
[HTML][HTML] Insights for stratification of risk in Brugada syndrome
Brugada syndrome (BrS) is an inherited disease with an increased risk of sudden cardiac
death (SCD). However, testing identifies genetic disorders in only 20–30% of patients …
death (SCD). However, testing identifies genetic disorders in only 20–30% of patients …
Novel therapeutic strategies for the management of ventricular arrhythmias associated with the Brugada syndrome
B Patocskai, C Antzelevitch - Expert opinion on orphan drugs, 2015 - Taylor & Francis
Introduction: The Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome
characterized by prominent J waves appearing as distinct coved type ST segment elevation …
characterized by prominent J waves appearing as distinct coved type ST segment elevation …
Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome
JM Cordeiro, H Barajas-Martinez, K Hong… - Circulation, 2006 - Am Heart Assoc
Background—Loss-of-function mutations in SCN5A have been associated with the Brugada
syndrome. We report the first Brugada syndrome family with compound heterozygous …
syndrome. We report the first Brugada syndrome family with compound heterozygous …
Why is only type 1 electrocardiogram diagnostic of Brugada syndrome? Mechanistic insights from computer modeling
Background: Three types of characteristic ST-segment elevation are associated with
Brugada syndrome but only type 1 is diagnostic. Why only type 1 ECG is diagnostic remains …
Brugada syndrome but only type 1 is diagnostic. Why only type 1 ECG is diagnostic remains …
[HTML][HTML] Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada syndrome: an updated systematic review and meta-analysis
Brugada syndrome (BrS) is primary electrical disorder characterized by ST segment
elevation with right bundle branch block morphology in patients with apparent structurally …
elevation with right bundle branch block morphology in patients with apparent structurally …
[HTML][HTML] Worldwide prevalence of Brugada syndrome: a systematic review and meta-analysis
W Vutthikraivit, P Rattanawong… - Acta Cardiologica …, 2018 - ncbi.nlm.nih.gov
Background Brugada syndrome (BrS) is considered to be an inherited arrhythmic disease
associated with fatal complications and premature sudden unexpected death. The …
associated with fatal complications and premature sudden unexpected death. The …