Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome

D Hu, H Barajas-Martínez, R Pfeiffer, F Dezi… - Journal of the American …, 2014 - jacc.org
Background: BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …

Brugada syndrome

B Benito, R Brugada, J Brugada, P Brugada - Progress in cardiovascular …, 2008 - Elsevier
Since its first description in 1992 as a new clinical entity, the Brugada syndrome has
aroused great interest among physicians and basic scientists. Two consensus conferences …

Brugada syndrome: clinical, genetic, molecular, cellular and ionic aspects

C Antzelevitch - Expert review of cardiovascular therapy, 2003 - Taylor & Francis
Brugada syndrome, first described as a new clinical entity by Pedro and Josep Brugada in
1992, has attracted great interest because of its high prevalence in many regions of the …

Commentary on the Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome

P Brugada - Circulation: Arrhythmia and Electrophysiology, 2010 - Am Heart Assoc
Eighteen years2 after the initial description of 8 patients with what has become known as
Brugada syndrome, this disease has changed from an ECG curiosity to a diagnosis to be …

[HTML][HTML] Insights for stratification of risk in Brugada syndrome

DG Iglesias, J Rubín, D Pérez, C Morís… - European Cardiology …, 2019 - ncbi.nlm.nih.gov
Brugada syndrome (BrS) is an inherited disease with an increased risk of sudden cardiac
death (SCD). However, testing identifies genetic disorders in only 20–30% of patients …

Novel therapeutic strategies for the management of ventricular arrhythmias associated with the Brugada syndrome

B Patocskai, C Antzelevitch - Expert opinion on orphan drugs, 2015 - Taylor & Francis
Introduction: The Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome
characterized by prominent J waves appearing as distinct coved type ST segment elevation …

Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome

JM Cordeiro, H Barajas-Martinez, K Hong… - Circulation, 2006 - Am Heart Assoc
Background—Loss-of-function mutations in SCN5A have been associated with the Brugada
syndrome. We report the first Brugada syndrome family with compound heterozygous …

Why is only type 1 electrocardiogram diagnostic of Brugada syndrome? Mechanistic insights from computer modeling

Z Zhang, PS Chen, JN Weiss, Z Qu - Circulation: Arrhythmia and …, 2022 - Am Heart Assoc
Background: Three types of characteristic ST-segment elevation are associated with
Brugada syndrome but only type 1 is diagnostic. Why only type 1 ECG is diagnostic remains …

[HTML][HTML] Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada syndrome: an updated systematic review and meta-analysis

A Bayoumy, MQ Gong, KHC Li, SH Wong… - Journal of geriatric …, 2017 - ncbi.nlm.nih.gov
Brugada syndrome (BrS) is primary electrical disorder characterized by ST segment
elevation with right bundle branch block morphology in patients with apparent structurally …

[HTML][HTML] Worldwide prevalence of Brugada syndrome: a systematic review and meta-analysis

W Vutthikraivit, P Rattanawong… - Acta Cardiologica …, 2018 - ncbi.nlm.nih.gov
Background Brugada syndrome (BrS) is considered to be an inherited arrhythmic disease
associated with fatal complications and premature sudden unexpected death. The …