Chronic pain is highly prevalent in the pediatric population. Many factors are involved in the
transition from acute to chronic pain. Currently, there are conceptual models proposed, but …

This topical review presents the current challenges in defining chronic pain in infants,
summarizes evidence from animal and human infant studies regarding the biological …

Understanding the predisposing factors that confer a greater risk of developing chronic pain
is an essential step in pain prevention and management. This chapter focuses on current …

Historically, only a few studies addressed the prevalence of acute and chronic pain in
infants, older children, and adolescents across multiple settings. Typically, there was a …

Recent attention to pain in neonates and young infants has resulted in a better
understanding of the underlying anatomy and physiology of pain transmission in this …

Biomarkers are common in all areas of clinical work, health research, and are critical
indicators of diseases and physiological states. Preferably, a biomarker should be non …

The prevalence and severity of chronic pain is well defined in children and adults.
Epidemiological studies estimate that 11% to 38% of children25 and 35% to 51% of …

Assessment provides the foundation for diagnosis, selection of treatments, and evaluation of
treatment effectiveness for pediatric patients with acute, recurrent, and chronic pain …

Pediatric chronic pain is a significant problem associated with substantial functional
impairment. A variety of risk factors have been found to be associated with chronic pain in …

When I first began my career in pediatric pain research 25 years ago, I could fit every
published article in the area in one cardboard file box. Since then, the field of pediatric pain …