The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Parkinson's disease (PD) is an incurable neurodegenerative disorder leading to progressive
motor impairment and for which there is no cure. From the first postmortem account …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
exact causes of neuronal damage are unknown, but mounting evidence indicates that …

Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Mitochondria are essential for cellular function due to their role in ATP production, calcium
homeostasis and apoptotic signalling. Neurons are heavily reliant on mitochondrial integrity …