[PDF][PDF] Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase
Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …
[PDF][PDF] An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors
B Orr, F De Sousa, AM Gomes, O Afonso, LT Ferreira… - Cell Reports, 2021 - cell.com
Micronuclei are a hallmark of cancer and several other human disorders. Recently,
micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements …
micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements …
[HTML][HTML] Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes
Chromosomes must establish stable biorientation prior to anaphase to achieve faithful
segregation during cell division. The detailed process by which chromosomes are bioriented …
segregation during cell division. The detailed process by which chromosomes are bioriented …
[PDF][PDF] Aurora A kinase contributes to a pole-based error correction pathway
Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from
opposing spindle poles, is the configuration that best ensures equal partitioning of the …
opposing spindle poles, is the configuration that best ensures equal partitioning of the …
[PDF][PDF] Feedback control in sensing chromosome biorientation by the Aurora B kinase
Maintenance of genome stability during cell division depends on establishing correct
attachments between chromosomes and spindle microtubules. Correct, bioriented …
attachments between chromosomes and spindle microtubules. Correct, bioriented …
[PDF][PDF] Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors
Merotelic kinetochore orientation is a misattachment in which a single kinetochore binds
microtubules from both spindle poles rather than just one and can produce anaphase …
microtubules from both spindle poles rather than just one and can produce anaphase …
[PDF][PDF] Captivating capture: how microtubules attach to kinetochores
S Biggins, CE Walczak - Current Biology, 2003 - cell.com
Accurate chromosome segregation is essential to ensure genomic stability because the
aneuploidy that results from segregation errors leads to birth defects and contributes to the …
aneuploidy that results from segregation errors leads to birth defects and contributes to the …
[PDF][PDF] The Aurora B gradient sustains kinetochore stability in anaphase
D Papini, MD Levasseur, JMG Higgins - Cell Reports, 2021 - cell.com
Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and
bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B …
bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B …
[PDF][PDF] Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase
DH Parry, GRX Hickson, PH O'Farrell - Current biology, 2003 - cell.com
Successful mitosis requires that anaphase chromosomes sustain a commitment to move to
their assigned spindle poles. This requires stable spindle attachment of anaphase …
their assigned spindle poles. This requires stable spindle attachment of anaphase …
[PDF][PDF] Tension-induced error correction and not kinetochore attachment status activates the SAC in an Aurora-B/C-dependent manner in oocytes
Cell division with partitioning of the genetic material should take place only when paired
chromosomes named bivalents (meiosis I) or sister chromatids (mitosis and meiosis II) are …
chromosomes named bivalents (meiosis I) or sister chromatids (mitosis and meiosis II) are …