[PDF][PDF] Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase

O Sen, JU Harrison, NJ Burroughs, AD McAinsh - Developmental cell, 2021 - cell.com
Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …

[PDF][PDF] An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors

B Orr, F De Sousa, AM Gomes, O Afonso, LT Ferreira… - Cell Reports, 2021 - cell.com
Micronuclei are a hallmark of cancer and several other human disorders. Recently,
micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements …

[HTML][HTML] Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes

TS Kitajima, M Ohsugi, J Ellenberg - Cell, 2011 - cell.com
Chromosomes must establish stable biorientation prior to anaphase to achieve faithful
segregation during cell division. The detailed process by which chromosomes are bioriented …

[PDF][PDF] Aurora A kinase contributes to a pole-based error correction pathway

AY Anna, J Deretic, CM Hoel, AW Hinman, D Cimini… - Current Biology, 2015 - cell.com
Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from
opposing spindle poles, is the configuration that best ensures equal partitioning of the …

[PDF][PDF] Feedback control in sensing chromosome biorientation by the Aurora B kinase

KJ Salimian, ER Ballister, EM Smoak, S Wood… - Current Biology, 2011 - cell.com
Maintenance of genome stability during cell division depends on establishing correct
attachments between chromosomes and spindle microtubules. Correct, bioriented …

[PDF][PDF] Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors

D Cimini, X Wan, CB Hirel, ED Salmon - Current Biology, 2006 - cell.com
Merotelic kinetochore orientation is a misattachment in which a single kinetochore binds
microtubules from both spindle poles rather than just one and can produce anaphase …

[PDF][PDF] Captivating capture: how microtubules attach to kinetochores

S Biggins, CE Walczak - Current Biology, 2003 - cell.com
Accurate chromosome segregation is essential to ensure genomic stability because the
aneuploidy that results from segregation errors leads to birth defects and contributes to the …

[PDF][PDF] The Aurora B gradient sustains kinetochore stability in anaphase

D Papini, MD Levasseur, JMG Higgins - Cell Reports, 2021 - cell.com
Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and
bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B …

[PDF][PDF] Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase

DH Parry, GRX Hickson, PH O'Farrell - Current biology, 2003 - cell.com
Successful mitosis requires that anaphase chromosomes sustain a commitment to move to
their assigned spindle poles. This requires stable spindle attachment of anaphase …

[PDF][PDF] Tension-induced error correction and not kinetochore attachment status activates the SAC in an Aurora-B/C-dependent manner in oocytes

A Vallot, I Leontiou, D Cladière, W El Yakoubi, S Bolte… - Current Biology, 2018 - cell.com
Cell division with partitioning of the genetic material should take place only when paired
chromosomes named bivalents (meiosis I) or sister chromatids (mitosis and meiosis II) are …