[图书][B] Effect of Draxin Manipulation on BTBR Mouse Brain and Behavior
A Blau - 2020 - search.proquest.com
Abstract Autism Spectrum Disorder (ASD) is known for distinct behavioral phenotypes such
as a preference for repetitive activities and difficulty in socialization. However, little is known …
as a preference for repetitive activities and difficulty in socialization. However, little is known …
Analysis of structural variation among inbred mouse strains
Background 'Long read'sequencing methods have been used to identify previously
uncharacterized structural variants that cause human genetic diseases. Therefore, we …
uncharacterized structural variants that cause human genetic diseases. Therefore, we …
Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism
OY Chao, E Marron Fernandez de Velasco… - …, 2020 - nature.com
Autism spectrum disorder (ASD) encompasses wide-ranging neuropsychiatric symptoms
with unclear etiology. Although the cerebellum is a key region implicated in ASD, it remains …
with unclear etiology. Although the cerebellum is a key region implicated in ASD, it remains …
Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism
N Cheng, F Alshammari, E Hughes, M Khanbabaei… - PLoS …, 2017 - journals.plos.org
Autism spectrum disorder (hereafter referred to as “ASD”) is a heterogeneous
neurodevelopmental condition characterized by impaired social communication and …
neurodevelopmental condition characterized by impaired social communication and …
Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice
EA Kiffmeyer, JA Cosgrove, JK Siganos, HE Bien… - NeuroSci, 2022 - mdpi.com
Recently, there has been increased interest in the role of the cerebellum in autism spectrum
disorder (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it …
disorder (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it …
Cognitive and Social Impairment in Mouse Models Mirrors Dravet Syndrome: Cognitive and Social Impairment in Dravet Mice
JA Kearney - Epilepsy Currents, 2013 - journals.sagepub.com
The models are an Scn1a+/-knockout mouse developed in the laboratory of Dr. William
Catterall (4) and a mouse engineered with the Dravet syndrome mutation SCN1A-R1407X …
Catterall (4) and a mouse engineered with the Dravet syndrome mutation SCN1A-R1407X …
An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development
CW Lin, J Ellegood, K Tamada, I Miura, M Konda… - Molecular …, 2023 - nature.com
Abstract The BTBR T+ Itpr3 tf/J (BTBR/J) strain is one of the most valid models of idiopathic
autism, serving as a potent forward genetics tool to dissect the complexity of autism. We …
autism, serving as a potent forward genetics tool to dissect the complexity of autism. We …
Author Correction: Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
A Ricobaraza, L Mora-Jimenez, E Puerta… - Scientific Reports, 2021 - nature.com
“Of note, a knock-in model harboring the same mutation (B6 (Cg)-Scn1atm1. 1Dsf/J strain
crossed with Cox2-Cre expressing mice) has been recently adopted by the US National …
crossed with Cox2-Cre expressing mice) has been recently adopted by the US National …
Comparative Gene Expression Analysis of Two Mouse Models of Autism: Transcriptome Profiling of the BTBR and En2−/− Hippocampus
G Provenzano, Z Corradi, K Monsorno… - Frontiers in …, 2016 - frontiersin.org
Autism spectrum disorders (ASD) are characterized by a high degree of genetic
heterogeneity. Genomic studies identified common pathological processes underlying the …
heterogeneity. Genomic studies identified common pathological processes underlying the …
Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
L Mora-Jimenez, M Valencia… - … Therapy-Nucleic Acids, 2021 - cell.com
Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …