Gliotoxin (GT) is a mycotoxin produced by some species of ascomycete fungi including the
opportunistic human pathogen Aspergillus fumigatus. In order to produce GT the host …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …

Gliotoxin is a redox-active nonribosomal peptide produced by Aspergillus fumigatus. Like
many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is …

The epipolythiodioxopiperazine (ETP) gliotoxin mediates toxicity via its reactive thiol groups
and thereby contributes to virulence of the human pathogenic fungus Aspergillus fumigatus …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Gliotoxin (1), a virulence factor of the human pathogenic fungus Aspergillus fumigatus, is the
prototype of epipoly (thiodioxopiperazine)(ETP) toxins. Here we report the discovery and …

Fungal sulfur uptake is required for incorporation into the sidechains of the amino acids
cysteine and methionine, and is also essential for the biosynthesis of the antioxidant …

Gliotoxin, and other related molecules, are encoded by multi-gene clusters and
biosynthesized by fungi using non-ribosomal biosynthetic mechanisms. Almost universally …