Abstract Human Leukocyte Antigen (HLA) complexes are critical cell-surface protein
assemblies that facilitate T-cell surveillance of almost all cell types in the body. While T-cell …

Presentation of antigens by human leukocyte antigen (HLA) complexes at the cell surface is
a key process in the immune response. The α-chain, containing the peptide-binding groove …

HLA class Ι molecules can communicate a range of cellular alterations (mutations, changes
in protein copy number, aberrant post-translational modifications, or pathogen proteins) to …

Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA)
class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated …

Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …

Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a
crucial role in adaptive immunology, mediating the communication between T cells and …

The majority of> 2000 HLA class I molecules can be clustered according to overlapping
peptide binding specificities or motifs recognized by CD8+ T cells. HLA class I motifs are …

HLA molecules are cell-surface glycoproteins that present peptides, derived from
intracellular protein antigens, for surveillance by T lymphocytes. Secreted HLA (sHLA) …

The human leukocyte antigen (HLA) complex regulates the adaptive immune response by
showcasing the intracellular and extracellular protein content to the immune system, where …

Peptide presentation by MHC class I and MHC class II molecules plays important roles in the
regulation of the immune response. One factor in these displays is the density of antigen …