If not cured promptly, tissue ischemia and hypoxia can cause serious consequences or even
threaten the life of the patient. Hemoglobin-based oxygen carrier-201 (HBOC-201), bovine …

Background: Producing an alternative to human erythrocytes has been one the most exciting
dreams of medicine. Hemoglobin-based oxygen carriers (HBOCs) derived from purified …

Hemopure®(HBOC-201, hemoglobin glutamer-250 (bovine)) is Biopure's third-generation
product belonging to a new class of biologic oxygen therapeutics, hemoglobin-based …

For the treatment of substantial blood loss in surgery, allogeneic blood is transfused to
maintain stability and organ perfusion and function. Continued concerns about the …

For several decades a wide variety of strategies have been investigated for the replacement
of stored red blood cells (RBCs) by" blood substitutes." Currently the most common method …

Because of an impending shortfall of allogeneic blood products within the next decades and
ongoing problems associated with relevant costs for testing and storage of banked red blood …

Lessons learned during 1,701 clinical uses of HBOC-201, a polymerized bovine hemoglobin-
based oxygen carrier (HBOC), were identified to provide management lessons and training …

HBOC-201 (Haemoglobin glutamer-250 [bovine]; Hemopure®) is a polymerised, iso-oncotic,
high-molecular weight, bovine haemoglobin-based oxygen carrier (HBOC) for intravenous …

Red blood cell (RBC) replacement solutions are being developed as alternatives to
allogeneic RBC use in blood transfusions in the treatment of massive trauma, to achieve …

Concerns about the infectious and immunosuppressive risks of allogeneic blood products
persist, and the increased disproportion of blood donation and consumption has reinforced …