Background Eya1 is a critical regulator of nephron progenitor cell specification and interacts
with Six2 to promote NPC self-renewal. Haploinsufficiency of these genes causes kidney …

Self-renewal and proliferation of nephron progenitor cells and the decision to initiate
nephrogenesis are crucial events directing kidney development. Despite recent …

Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). It belongs
to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA …

Nephron progenitor number determines nephron endowment; a reduced nephron count is
linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1 …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Mammalian nephrons originate from a population of nephron progenitor cells, and changes
in these cells' transcriptomes contribute to the cessation of nephrogenesis, an important …

The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and
have since diverged in their developmental expression patterns. Both genes are expressed …

Background We reasoned that unraveling the dynamic changes in accessibility of genomic
regulatory elements and gene expression at single-cell resolution will inform the basic …

Mammalian kidneys maintain fluid homeostasis through the cellular activity of nephrons and
the conjoined collecting system. Each epithelial network originates from distinct progenitor …

In mammals, formation of new nephrons ends perinatally due to consumption of
mesenchymal progenitor cells. Premature depletion of progenitors due to prematurity or …