Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs
from their microenvironment and cells themselves. Emerging as critical regulators of the …

The hematopoietic system is dynamic during development and in adulthood, undergoing
countless spatial and temporal transitions during the course of one's life …

Abstract Purpose of Review Hematopoietic stem cells (HSCs) are reliant on intrinsic and
extrinsic factors for tight control of self-renewal, quiescence, differentiation, and homing …

Biomechanics is known to play an important role in cell metabolism. Cell phenotype, tissue-
specific functions, and fate critically depend on the extracellular mechanical environment …

Stem cells are undifferentiated cells that are capable of proliferation, self‐maintenance and
differentiation towards specific cell phenotypes. These processes are controlled by a variety …

Experimental control over progenitor cell lineage specification can be achieved by
modulating properties of the cell's microenvironment. These include physical properties of …

In recent years, it has become clear that mechanical cues play an integral role in
maintaining stem cell functions. Here we discuss how integrating physical approaches and …

Adult stem cells and progenitors are of great interest for their clinical application as well as
their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is …

Mechanical forces, including gravity, tension, compression, hydrostatic pressure, and fluid
shear stress, play a vital role in human physiology and pathology. They particularly influence …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …