Our understanding of the genetics and the pathophysiology of asthma has greatly improved
over the past decade. This in addition to recent clinical trials has enabled preventative …

Asthma is a clinically heterogeneous inflammatory disorder characterized by variable and
recurring symptoms of airflow obstruction. This chapter briefly describes the genetic and …

Severe asthma in children is characterized by sustained symptoms despite treatment with
high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma …

This book provides readers with a comprehensive review of severe asthma in children and
adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical …

Recent statistics have shown that asthma deaths and hospitalizations are decreasing, but
there are unmet challenges in the management of severe asthma in children. Current …

109 Vol. 5-No. 5 Sep-Oct 2018 there is no single genetic or environmental cause. Asthma is
simply defined on the basis of clinical symptoms as it is not a fixed disease being a …

Asthma is a heterogeneous disease with numerous clinical phenotypes. Severe asthma
constitutes about 10% of all cases of asthma. There is significant geographic and regional …

Asthma is an inflammatory disease with easily recognized clinical signs and symptoms. The
challenges in management of patients with asthma however are the recognition of the …

Children with severe asthma continue to experience symptoms despite long-term treatment
with high doses of corticosteroids. Moreover, the heterogeneous nature of asthma and the …

The global burden of asthme and its treatment is huge (1), and is reviewed by Ferrante and
La Grutta. Part of the problem requires a political solution; in large parts of the world …