The devastating effect of ischemic stroke is attenuated in mice lacking conventional and
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …

Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells
are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent …

Background and Purpose—Inflammatory mechanisms can exacerbate ischemic tissue
damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are …

T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion
injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a …

Stroke is a leading cause of physical disability with neurodegenerative sequelae such as
dementia and depression causing significant excess morbidity. Stroke severity can be …

Lymphocyte recruitment and activation have been implicated in the progression of cerebral
ischemia-reperfusion (I/R) injury, but the roles of specific lymphocyte subpopulations and …

Background and Purpose—Immune-mediated tissue damage after stroke evolves within the
first days, and lymphocytes contribute to the secondary injury. Our goal was to identify T-cell …

Summary Interleukin‐17 (IL‐17) is a cytokine family that includes 6 members, IL‐17A
through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to …

The brain and the immune system interact in complex ways after ischemic stroke, and the
long-term effects of immune response associated with stroke remain controversial. As a …

Clinical stroke induces inflammatory processes leading to cerebral injury. IL-10 expression
is elevated during major CNS diseases and limits inflammation in the brain. Recent …