[PDF][PDF] Implication of SEMA3C-induced steroidogenesis in the progression of castration-resistant prostate cancer
P Yenki - 2020 - open.library.ubc.ca
Androgens ie testosterone (T) and dihydrotestosterone (DHT), have essential roles in the
differentiation and growth of normal prostate cells, as well as in the progression of prostate …
differentiation and growth of normal prostate cells, as well as in the progression of prostate …
[HTML][HTML] Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells
P Yenki, S Bhasin, L Liu, N Nabavi… - Endocrine-related …, 2023 - erc.bioscientifica.com
Intratumoral androgen biosynthesis contributes to castration-resistant prostate cancer
progression in patients treated with androgen deprivation therapy. The molecular …
progression in patients treated with androgen deprivation therapy. The molecular …
SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling
P Yenki, HH Adomat, CJ Ong - The Prostate, 2021 - Wiley Online Library
Background Castration resistant prostate cancer progression is associated with an acquired
intratumoral androgen synthesis. Signaling pathways that can upregulate androgen …
intratumoral androgen synthesis. Signaling pathways that can upregulate androgen …
Targeting semaphorin 3C in prostate cancer with small molecules
CCW Lee, RSN Munuganti, JW Peacock… - Journal of the …, 2018 - academic.oup.com
Despite the amenability of early-stage prostate cancer to surgery and radiation therapy,
locally advanced and metastatic prostate cancer is clinically problematic. Chemical …
locally advanced and metastatic prostate cancer is clinically problematic. Chemical …
[HTML][HTML] Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner
KJ Tam, K Dalal, M Hsing, CW Cheng, S Khosravi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The androgen receptor (AR) is a member of the nuclear receptor superfamily of transcription
factors and is central to prostate cancer (PCa) progression. Ligand-activated AR engages …
factors and is central to prostate cancer (PCa) progression. Ligand-activated AR engages …
Prostate cancer cells induce osteoblastic differentiation via semaphorin 3A
F Liu, W Shen, H Qiu, X Hu, C Zhang, T Chu - The Prostate, 2015 - Wiley Online Library
BACKGROUND Prostate cancer metastasis to bone is the second most commonly
diagnosed malignant disease among men worldwide. Such metastatic disease is …
diagnosed malignant disease among men worldwide. Such metastatic disease is …
Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells
KJ Tam, DHF Hui, WW Lee, M Dong, T Tombe… - Scientific reports, 2017 - nature.com
Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a
leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited …
leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited …
Semaphorin 3C as a therapeutic target in prostate and other cancers
DHF Hui, KJ Tam, IZF Jiao, CJ Ong - International Journal of Molecular …, 2019 - mdpi.com
The semaphorins represent a large family of signaling molecules with crucial roles in
neuronal and cardiac development. While normal semaphorin function pertains largely to …
neuronal and cardiac development. While normal semaphorin function pertains largely to …
[HTML][HTML] SEMA4A promotes prostate cancer invasion: involvement of tumor microenvironment
X Liu, W Tan, W Wang, T Feng, C Wang, L Wang… - Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Semaphorin 4A (SEMA4A) belonged to a family of membrane-bound proteins that
were initially recognized as a kind of axon guidance factors in nervous system. It was …
were initially recognized as a kind of axon guidance factors in nervous system. It was …
SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance
F Liu, C Wang, H Huang, Y Yang, L Dai… - Cellular & Molecular …, 2021 - nature.com
Androgen deprivation therapy (ADT) is an important treatment strategy that can be used to
delay the progression of prostate cancer. However, after an initial response, which varies …
delay the progression of prostate cancer. However, after an initial response, which varies …