Forkhead box P2 (FOXP2) is a highly conserved transcription factor that has been implicated
in human speech and language disorders and plays important roles in the plasticity of the …

FOXP2-related speech and language disorder (FOXP2-SLD) is caused by heterozygous
FOXP2 pathogenic variants (including whole-or partial-gene deletions). The core phenotype …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …

Previous studies have demonstrated that mutation in the forkhead domain of the forkhead
box P2 (FOXP2) protein (R553H) causes speech-language disorders. To further analyze …

Objective To provide new insights into the FOXG1-related clinical and imaging phenotypes
and refine the phenotype-genotype correlation in FOXG1 syndrome. Methods We analyzed …

Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-
described examples of monogenic speech and language disorders. Acquisition of proficient …

Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental diseases.
It is important to characterize the cell types that express Foxp1 and Foxp2 in the brain. Foxp1 …

FoxP2 mutations in humans are associated with a disorder that affects both the
comprehension of language and its production, speech. This discovery provided the first …

▪ Abstract A significant number of individuals have unexplained difficulties with acquiring
normal speech and language, despite adequate intelligence and environmental stimulation …