Interleukin-30 Suppresses Not Only CD4+ T Cells but Also Regulatory T Cells in Murine Primary Biliary Cholangitis

HW Chen, CI Lin, YH Chuang - Biomedicines, 2021 - mdpi.com
Primary biliary cholangitis (PBC) is a chronic liver autoimmune disease with augmented T
helper (Th) 1 and corresponding cytokine IFN-γ immune responses. Using 2-octynoic acid (2 …

[HTML][HTML] Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression

S Støy, TL Laursen, E Glavind, PL Eriksen… - Clinical and …, 2020 - journals.lww.com
METHODS: We prospectively studied 41 consecutive patients with AH at diagnosis, days 7
and 90, and followed them for up to 1 year. We measured IL-22 pathway proteins in liver …

Expression of interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection

WJ Du, JH Zhen, ZQ Zeng, ZM Zheng, Y Xu, LY Qin… - Diagnostic …, 2013 - Springer
Background/objectives As a proinflammatory cytokine, interleukin-17 (IL-17) contributes to
the inflammation of many autoimmune diseases. We examined IL-17 levels in serum and …

Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis

X Yang, L Liao, Z Liang, S Yu, Z Guo - Journal of Inflammation …, 2024 - Taylor & Francis
Objective This research aimed to explore the involvement of interleukins (IL)-IL-6, IL-17, IL-
21, and IL-23-in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis …

Interleukin-23 mediates the pathogenesis of LPS/GalN-induced liver injury in mice

S Bao, Q Zhao, J Zheng, N Li, C Huang, M Chen… - International …, 2017 - Elsevier
Abstract Background Interleukin-23 (IL-23) is required for T helper 17 (Th17) cell responses
and IL-17 production in hepatitis B virus infection. A previous study showed that the IL-23/IL …

Role of interleukin-22 in liver diseases

C Pan, J Tang, X Wang, F Wu, J Ge, F Chen - Inflammation Research, 2014 - Springer
Abstract Introduction Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-
derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly …

Role of IL-24 in the mucosal remodeling of children with coeliac disease

R Rokonay, A Veres-Székely, B Szebeni, D Pap… - Journal of translational …, 2020 - Springer
Background Recently, involvement of IL-19, IL-20 and IL-24 has been reported in
inflammatory diseases associated with tissue remodeling. However, their impact on the …

Expression levels of IL-37 and HBeAg seroconversion in chronic HBV patients

J Liu, Q LI, S Guan, C Liu, Y HE… - Chinese Journal of …, 2015 - pesquisa.bvsalud.org
Objective: Detecting serum IL-37 concentrations and HBeAg seroconversion in chronic
hepatitis B virus (HBV) patients during the treatment of telbivudine (LDT). Methods: Fifty …

Interleukin-35 Suppresses CD8+ T Cell Activity in Patients with Viral Hepatitis-Induced Acute-on-Chronic Liver Failure

L Yang, Q Zhang, J Song, W Wang, Z Jin - Digestive diseases and …, 2020 - Springer
Abstract Background Interleukin (IL)-35 is a newly indentified cytokine and induces
immunotolerance via suppression of CD8+ T cell activity in chronic viral hepatitis. Aims To …

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

KM Schwarzkopf, L Eberle, FE Uschner… - Journal of …, 2020 - journal-of-hepatology.eu
Xiang et al. published interesting insights about the role of interleukin (IL)-22 in acute-on-
chronic liver failure (ACLF). 1 The authors elegantly analysed the effects of IL-22 in a mouse …