Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis

Q Bai, M Shi, X Sun, Q Lou, H Peng, Z Qu… - Frontiers in …, 2022 - frontiersin.org
Background N6-methyladenosine (m6A) modification is a critical epigenetic modification in
eukaryotes and involves several biological processes and occurrences of diseases …

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis

Y Qiao, J Li, D Liu, C Zhang, Y Liu, S Zheng - Frontiers in genetics, 2023 - frontiersin.org
Osteoporosis (OP) is a severe systemic bone metabolic disease that occurs worldwide.
During the coronavirus pandemic, prioritization of urgent services and delay of elective care …

Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis

X Chen, W Hua, X Huang, Y Chen, J Zhang… - Frontiers in …, 2020 - frontiersin.org
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

[HTML][HTML] The essential roles of m6A modification in osteogenesis and common bone diseases

Y Gu, Y Song, Y Pan, J Liu - Genes & Diseases, 2024 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most prevalent modification in the eukaryotic
transcriptome and has a wide range of functions in coding and noncoding RNAs. It affects …

m6A methylation regulates osteoblastic differentiation and bone remodeling

M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …

Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density

XB Mo, YH Zhang, SF Lei - Osteoporosis International, 2018 - Springer
This study investigated the effect of the N 6-methyladenosine (m 6 A)-associated SNPs on
bone mineral density (BMD) and found plenty of m 6 A-SNPs that were associated with …

The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis

Y Li, L Meng, B Zhao - Pharmacology & therapeutics, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A), a novel epitranscriptomic RNA modification, plays
crucial roles in a variety of biological processes and diseases. Recently, there are growing …

The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG

L Chen, M Zhang, P Chen, X Xiong, P Liu… - Acta Pharmacologica …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional methylation
modification that occurs in mRNA and modulates the fine-tuning of various biological …

N6-Methyladenosine in Cell-Fate Determination of BMSCs: From Mechanism to Applications

Q Zhang, J Li, C Wang, Z Li, P Luo, F Gao, W Sun - Research, 2024 - spj.science.org
The methylation of adenosine base at the nitrogen-6 position is referred to as “N6-
methyladenosine (m6A)” and is one of the most prevalent epigenetic modifications in …

Bioinformatics identification and experimental validation of m6A-related diagnostic biomarkers in the subtype classification of blood monocytes from postmenopausal …

P Zhang, H Chen, B Xie, W Zhao, Q Shang… - Frontiers in …, 2023 - frontiersin.org
Background Postmenopausal osteoporosis (PMOP) is a common bone disorder. Existing
study has confirmed the role of exosome in regulating RNA N6-methyladenosine (m6A) …