[HTML][HTML] Topical treatments and their molecular/cellular mechanisms in patients with peripheral neuropathic pain—narrative review

M Kocot-Kępska, R Zajączkowska, J Mika, DJ Kopsky… - Pharmaceutics, 2021 - mdpi.com
Neuropathic pain in humans results from an injury or disease of the somatosensory nervous
system at the peripheral or central level. Despite the considerable progress in pain …

[HTML][HTML] Multimodal approaches to the management of neuropathic pain: the role of topical analgesia

OA de Leon-Casasola - Journal of pain and symptom management, 2007 - Elsevier
Because of their localized activity and low systemic absorption, topical analgesics have a
favorable safety profile and a low risk for drug-drug interactions. There is a growing body of …

[HTML][HTML] Peripheral mechanisms of neuropathic pain—the role of neuronal and non-neuronal interactions and their implications for topical treatment of neuropathic …

M Kocot-Kępska, R Zajączkowska, J Mika… - Pharmaceuticals, 2021 - mdpi.com
Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …

Topical drug therapeutics for neuropathic pain

TJ Coderre - Expert Opinion on Pharmacotherapy, 2018 - Taylor & Francis
Introduction: Neuropathic pain (NP) is a particularly severe and intractable chronic condition
that is not well treated by commonly recommended systemic pharmacological therapies …

Topical analgesics for neuropathic pain: preclinical exploration, clinical validation, future development

J Sawynok - European journal of pain, 2014 - Wiley Online Library
Topical analgesics applied locally to skin or to specialized compartments modify pain by
actions on sensory nerve endings and/or adjacent cellular elements. With this approach …

[HTML][HTML] Peripheral mechanisms of peripheral neuropathic pain

P Pacifico, JS Coy-Dibley, RJ Miller… - Frontiers in Molecular …, 2023 - frontiersin.org
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease
affecting the peripheral nervous system, is associated with an extremely large disease …

Management of chronic neuropathic pain with single and compounded topical analgesics

NN Knezevic, T Tverdohleb, F Nikibin… - Pain …, 2017 - Taylor & Francis
The goal of our review was to emphasize important aspects that physicians should take into
consideration when prescribing topical analgesics as part of chronic neuropathic pain …

Topical treatment of neuropathic pain using compounded medications

E Zur - The Clinical journal of pain, 2014 - journals.lww.com
Background: The current medical treatment of neuropathic pain (NP) is inadequate with
more than two thirds of patients having no suitable solution for their morbid disease and …

Translational investigation and treatment of neuropathic pain

B Xu, G Descalzi, HR Ye, M Zhuo… - Molecular …, 2012 - journals.sagepub.com
Neuropathic pain develops from a lesion or disease affecting the somatosensory system.
Translational investigations of neuropathic pain by using different animal models reveal that …

[HTML][HTML] Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for …

PJ Albrecht, Y Liu, G Houk, B Ruggiero, D Banov… - Pain …, 2024 - journals.lww.com
Objectives: The study intended to identify objective biomarkers in PHN skin on a patient-by-
patient personalized medicine platform. The totality of biopsy biomarker data can provide a …