Human Cell Line Panel With Human/Mouse Artificial Chromosomes for Functional Analyses of Desired Genes
N Uno, S Takata, S Komoto, H Miyamoto, Y Nakayaka… - 2021 - researchsquare.com
Human artificial chromosomes (HACs) and mouse artificial chromosomes (MACs) are non-
integrating chromosomal gene delivery vectors for molecular biology research. Recently …
integrating chromosomal gene delivery vectors for molecular biology research. Recently …
Panel of human cell lines with human/mouse artificial chromosomes
N Uno, S Takata, S Komoto, H Miyamoto… - Scientific Reports, 2022 - nature.com
Human artificial chromosomes (HACs) and mouse artificial chromosomes (MACs) are non-
integrating chromosomal gene delivery vectors for molecular biology research. Recently …
integrating chromosomal gene delivery vectors for molecular biology research. Recently …
A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges
M Oshimura, N Uno, Y Kazuki, M Katoh, T Inoue - Chromosome Research, 2015 - Springer
Microcell-mediated chromosome transfer (MMCT) is a technique to transfer a chromosome
from defined donor cells into recipient cells and to manipulate chromosomes as gene …
from defined donor cells into recipient cells and to manipulate chromosomes as gene …
New vectors for gene delivery: human and mouse artificial chromosomes
M Oshimura, Y Kazuki, Y Iida, N Uno - eLS, 2013 - Wiley Online Library
Human artificial chromosomes (HACs) have been generated mainly by either a 'top-down
approach'(engineered creation) or a 'bottom-up approach'(de novo creation). HACs with …
approach'(engineered creation) or a 'bottom-up approach'(de novo creation). HACs with …
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
M Kakeda, M Hiratsuka, K Nagata, Y Kuroiwa… - Gene therapy, 2005 - nature.com
Human artificial chromosomes (HACs) segregating freely from host chromosomes are
potentially useful to ensure both safety and duration of gene expression in therapeutic gene …
potentially useful to ensure both safety and duration of gene expression in therapeutic gene …
Transfer of human artificial chromosome vectors into stem cells
M Oshimura, M Katoh - Reproductive biomedicine online, 2008 - Elsevier
Human chromosome fragments and human artificial chromosomes (HAC) represent feasible
gene delivery vectors via microcell-mediated chromosome transfer. Strategies to construct …
gene delivery vectors via microcell-mediated chromosome transfer. Strategies to construct …
Current advances in microcell-mediated chromosome transfer technology and its applications
T Suzuki, Y Kazuki, T Hara, M Oshimura - Experimental Cell Research, 2020 - Elsevier
Chromosomes and chromosomal gene delivery vectors, human/mouse artificial
chromosomes (HACs/MACs), can introduce megabase-order DNA sequences into target …
chromosomes (HACs/MACs), can introduce megabase-order DNA sequences into target …
Transfer of synthetic human chromosome into human induced pluripotent stem cells for biomedical applications
SA Sinenko, EV Skvortsova, MA Liskovykh… - Cells, 2018 - mdpi.com
AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a
novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue …
novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue …
Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation
H Miyamoto, H Kobayashi, N Kishima… - Nucleic Acids …, 2024 - academic.oup.com
A 'genomically'humanized animal stably maintains and functionally expresses the genes on
human chromosome fragment (hCF;< 24 Mb) loaded onto mouse artificial chromosome …
human chromosome fragment (hCF;< 24 Mb) loaded onto mouse artificial chromosome …
Mammalian artificial chromosomes and clinical applications for genetic modification of stem cells: an overview
Modifying multipotent, self-renewing human stem cells with mammalian artificial
chromosomes (MACs), present a promising clinical strategy for numerous diseases …
chromosomes (MACs), present a promising clinical strategy for numerous diseases …