Because leukocyte-mediated tissue damage is an important component of the pathologic
picture in ischemia/reperfusion, we have sought mechanisms by which PMNs are directed …

Ischemia-reperfusion and hyperoxia-induced pulmonary injury are associated with the
presence of activated neutrophils (PMN) and cellular injury. Although the signals …

Tissue injury that accompanies hypoxemia/reoxygenation shares features with the host
response in inflammation, suggesting that cytokines, such as IL-1, may act as mediators in …

The pathologic picture in ischemic tissue injury shares features with the inflammatory
response, including production of proinflammatory cytokines. Hypoxia-mediated induction of …

The elicitation of leukocytes from the circulation to inflamed tissue depends on the activation
of both the leukocyte and endothelial cell. In this study we determined the gene expression …

Cellular constituents of the alveolar-capillary wall may be key participants in the recruitment
of polymorphonuclear leukocytes to the lung through the generation of the novel neutrophil …

The combined effects of hypoxia and interleukin 1, lipopolysaccharide, or tumor necrosis
factor alpha on the expression of genes encoding endothelial constitutive and inducible …

Using a rat model of acute lung inflammation induced by intratracheal instillation of
lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression and the …

To examine the possible involvement of cytokines in reperfusion injury, we have studied
production of IL-1 by human vascular cells, including smooth muscle and mononuclear …

Hypoxia is a common denominator of ischemic microenvironments. Endothelium subjected
to oxygen deprivation maintains cell viability and basic biosynthetic mechanisms, but …