Stroke is the third leading cause of mortality in women and it kills twice as many women as
breast cancer. A key role in the pathophysiology of stroke plays the disruption of the blood …

Background Stroke could lead to serious morbidity, of which ischemic stroke counts for
majority of the cases. Inflammation plays an important role in the pathogenesis of ischemic …

Little is known about estrogen receptors and their signaling mechanisms in human cerebral
vascular endothelial cells, which is important for understanding cerebral aneurysm …

G protein-coupled estrogen receptor 1 (GPER-1) plays important roles in estrogen-mediated
neuroprotection. However, protective effects of GPER-1 on blood-brain barrier (BBB) after …

Background: A strong body of evidence suggests that cerebrovascular pathologies augment
the onset and progression of Alzheimer's disease (AD). One distinctive aspect of this …

Estrogen receptors (ERs) play important roles in estrogen-mediated neuroprotection.
However, their effects on blood–brain barrier (BBB) disruption with vasogenic edema after …

Cerebrovascular changes occur in Alzheimer's disease (AD). The progesterone receptor
membrane component-1 (PGRMC1) is a well identified hormone receptor with multiple …

Disruption of the blood-brain barrier (BBB) integrity occurring during the early onset of stroke
is not only a consequence of, but also contributes to the further progression of stroke …

Background Increased matrix metalloproteinase (MMP)-9 in the plasma and brain is
associated with blood-brain barrier (BBB) disruption through proteolytic activity in …

Background and Purpose—Reduced risk and severity of stroke in adult females are thought
to depend on normal levels of endogenous estrogen, which is a known neuro-and …