Tissue-specific effects of leptin on glucose and lipid metabolism
The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …
However, the effects of leptin are more far-reaching and include profound glucose-lowering …
Rethinking leptin and insulin action: therapeutic opportunities for diabetes
BO Yildiz, IC Haznedaroglu - The international journal of biochemistry & …, 2006 - Elsevier
Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …
key role in the regulation of food intake, body weight, energy expenditure and …
Peripheral metabolic actions of leptin
DM Muoio, GL Dohm - Best Practice & Research Clinical Endocrinology & …, 2002 - Elsevier
The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …
The role of leptin in glucose homeostasis
HC Denroche, FK Huynh… - Journal of diabetes …, 2012 - Wiley Online Library
The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …
now substantial evidence that leptin also plays a primary role in the regulation of glucose …
Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals
HS Moon, M Dalamaga, SY Kim, SA Polyzos… - Endocrine …, 2013 - academic.oup.com
Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …
Leptin in human physiology and pathophysiology
CS Mantzoros, F Magkos… - American Journal …, 2011 - journals.physiology.org
Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …
hormone with pleiotropic effects in the physiology and pathophysiology of energy …
Leptin revisited: its mechanism of action and potential for treating diabetes
R Coppari, C Bjørbæk - Nature reviews Drug discovery, 2012 - nature.com
Since the discovery of leptin in 1994, we now have a better understanding of the cellular and
molecular mechanisms underlying its biological effects. In addition to its established anti …
molecular mechanisms underlying its biological effects. In addition to its established anti …
[HTML][HTML] Direct and indirect effects of leptin on adipocyte metabolism
RBS Harris - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2014 - Elsevier
Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …
[HTML][HTML] The glucoregulatory actions of leptin
AM D'souza, UH Neumann, MM Glavas, TJ Kieffer - Molecular metabolism, 2017 - Elsevier
Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …
inhibit food intake and increase energy expenditure. Leptin can also independently lower …
Leptin and clinical medicine: a new piece in the puzzle of obesity
GA Bray, DA York - The Journal of Clinical Endocrinology & …, 1997 - academic.oup.com
THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …