The aim of the current study was to investigate whether, and if so how, brain‐derived
neurotrophic factor (BDNF) acts to develop the spinal sensitization underlying inflammation …

It has been shown that following peripheral nerve injury brain-derived neurotrophic factor
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …

Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …

Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …

The primary sensory neurons that respond to noxious stimulation and project to the spinal
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …

Although known primarily for its role in neuronal development, brain-derived neurotrophic
factor (BDNF) has also recently been implicated in processes mediated by the adult nervous …

Neuropathic pain management is challenging for physicians and a vexing problem for basic
researchers. Recent studies reveal that activated spinal astrocytes may play a vital role in …

Numerous reported data support the idea that Brain Derived Neurotrophic Factor (BDNF) is
critically involved in both depression and comorbid pain. The possible direct effect of BDNF …

Peripheral nerve injury can promote neuropathic pain. The basis of the 'central
sensitization'that underlies this often intractable condition was investigated using 14–20‐day …

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two major
members of the neurotrophin family. Using immunohistochemistry and in situ hybridization …