An in vitro model to study the naïve human peripheral blood mononuclear cell response to Cryptococcus neoformans infection

K Pline, SA Johnston - bioRxiv, 2020 - biorxiv.org
Cryptococcus neoformans is a facultative intracellular pathogenic yeast which causes
cryptococcal meningitis. Infection most commonly occurs via the lungs in humans and is …

[PDF][PDF] Investigating the role of Cryptococcus neoformans-macrophage interactions on the outcome of cryptococcal infection

K Pline - 2020 - etheses.whiterose.ac.uk
Cryptococcus neoformans is a pathogenic yeast which causes cryptococcal meningitis in
immunocompromised patients, causing heterogeneous infection outcomes in both HIV …

[HTML][HTML] A Sensitive High-Throughput Assay for Evaluating Host-Pathogen Interactions in Cryptococcus neoformans Infection

D Srikanta, M Yang, M Williams, TL Doering - PLoS One, 2011 - journals.plos.org
Background Cryptococcus neoformans causes serious disease in immunocompromised
individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due to …

The multiplicity of infection does not affect interactions between Cryptococcus neoformans and macrophages

K Pline, S Johnston - bioRxiv, 2020 - biorxiv.org
Major determinants of the outcome of infection include growth of the pathogen and response
of immune cells such as macrophages. Cryptococcus neoformans is a fungal pathogen …

[HTML][HTML] Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

A Bojarczuk, KA Miller, R Hotham, A Lewis… - Scientific reports, 2016 - nature.com
Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

[HTML][HTML] Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

[HTML][HTML] The diverse roles of monocytes in Cryptococcosis

MS Fu, RA Drummond - Journal of Fungi, 2020 - mdpi.com
Monocytes are considered to play a central role in the pathogenesis of Cryptococcus
neoformans infection. Monocytes and monocyte-derived macrophages and dendritic cells …

[HTML][HTML] Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic …

RJA de Castro, CL Marina, A Sturny-Leclère… - PLoS …, 2023 - journals.plos.org
Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

Probing the innate immune response to invasive fungal infections

PI Seoane Denicola - 2020 - etheses.bham.ac.uk
Cryptococcus neoformans is an opportunistic fungal pathogen, which is widespread in the
environment. Due to its global distribution and association with pigeon excreta, human …

[HTML][HTML] Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans

BN Nelson, AN Hawkins, KL Wozniak - Frontiers in cellular and …, 2020 - frontiersin.org
The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …