Gene therapy aims at transferring a therapeutic gene into human somatic cells in order to
treat a disease. Originally addressed to hereditary genetic disorders, gene therapy has …

The structure of DNA was unraveled by Watson and Crick in 1953, and two decades later
Arber, Nathans and Smith discovered DNA restriction enzymes, which led to the rapid …

The material transferred is on the order of one to a few genes in size. Since many hereditary
diseases are caused by defects in single genes, there are many potential applications of this …

Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to
tissues for clinical applications has been discussed around half a century, but scientist's …

The development over the past decade of methods for delivering genes to mammalian cells
has stimulated great interest in the possibility of treating human disease by gene-based …

The gene therapy approach can vary from delivering extra copies of a gene, through
modifications of a genome using the properties of ribozymes or chimeraplasts, to injection of …

Gene therapy promises to revolutionize medicine by treating the causes of disease rather
than the symptoms. We are nearing the end of the first decade of gene therapy, and this …

Genetically modified animals are state of the art in biomedical research as gene therapy is a
promising perspective in the attempt to cure hereditary diseases. Both approaches have in …

Even though gene therapy made its way through the clinics to treat a number of human
pathologies since the early years of experimental research and despite the recent approval …

The ultimate goal in the management of inherited as well as acquired diseases is a rational
therapy with the aim to eliminate the underlying biochemical defects, rather than a …