Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the
internalisation of the drug at a sub-cellular level and reveals its accumulation within the …

Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing
these disorders. However, its use is limited by a wide range of adverse effects, mainly …

Detecting metabolites and parent compound within a cell type is now a priority for
pharmaceutical development. In this context, three-dimensional secondary ion mass …

Background and purpose: Tissue deposits of the anti‐arrhythmic drug amiodarone are a
major source of side effects (skin discoloration, etc.). We addressed the mechanism of the …

The analysis of large numbers of cells from a population results in information that does not
reflect differences in cell phenotypes. Individual variations in cellular drug uptake …

ToF-SIMS is a label-free imaging method that has been shown to enable imaging of
amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method …

Purpose Progress to the clinic may be delayed or prevented when vacuolated or “foamy”
alveolar macrophages are observed during non-clinical inhalation toxicology assessment …

Amiodarone is a cationic amphiphilic drug used as an antiarrhythmic agent. It induces
phospholipidosis, ie, the accumulation of phospholipids within organelles of the endosomal …

'Foamy'alveolar macrophages (FAM) observed in nonclinical toxicology studies during
inhaled drug development may indicate drug-induced phospholipidosis, but can also derive …

Nanotechnology is playing an increasing role in targeted drug delivery into pathological
tissues. Drug-loaded pharmaceutical nanocarriers can be delivered into diseased sites by …