Optimising selenium for modulation of cancer treatments

SO Evans, PF Khairuddin, MB Jameson - Anticancer research, 2017 - ar.iiarjournals.org
Selenium is an essential trace element involved in many biological processes that are
mediated through, at least, 25 selenoproteins expressed in humans. Extensive study of …

Selenoproteins and their role in oxidative stress and inflammation

UH Gandhi, TP Nagaraja… - Current chemical …, 2013 - ingentaconnect.com
The discovery of selenocysteine as the 21st amino acid has revolutionized the
understanding of the significance of the essential micronutrient selenium in human and …

Protective role of selenium compounds on the proliferation, apoptosis, and angiogenesis of a canine breast cancer cell line

Y Liu, W Li, M Guo, C Li, C Qiu - Biological trace element research, 2016 - Springer
We herein examined the effects of different doses, forms, and compatibilities of selenium on
a canine mammary gland tumor cell line, CTM1211, and explored the related mechanisms …

Toward understanding success and failures in the use of selenium for cancer prevention

H Steinbrenner, B Speckmann, H Sies - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Adequate and supranutritional selenium (Se) intake, maintaining full
expression of selenoproteins, has been assumed to be beneficial for human health with …

[PDF][PDF] Selenium is effective in inducing lymphocyte progression through cell cycle in cancer patients: potential mechanisms for its activity.

G Mantovani, A Macciò, C Madeddu… - Journal of …, 2004 - researchgate.net
2 1.5 µM enhanced significantly the progression into S phase of PBMCs isolated from
cancer patients, whilst no significant effect was observed on PBMCs isolated from controls …

Selenium and cancer

DL Hatfield, BA Carlson, PA Tsuji, R Tobe… - Molecular, genetic, and …, 2017 - Elsevier
Selenium is essential to mammals and many other life forms, but its ingested levels are
critical to health because too little or too much can have severe consequences on the well …

[HTML][HTML] The link between selenium and chemoprevention: a case for selenoproteins

V Diwadkar-Navsariwala, AM Diamond - The Journal of nutrition, 2004 - Elsevier
Selenium is effective in reducing cancer incidence in animal models, and epidemiologic
data, as well as supplementation trials, have indicated that selenium is likely to be effective …

Long-term selenium supplementation in HaCaT cells: importance of chemical form for antagonist (protective versus toxic) activities

F Hazane-Puch, P Champelovier, J Arnaud… - Biological trace element …, 2013 - Springer
The beneficial effect of selenium (Se) on cancer is known to depend on the chemical form,
the dose and the duration of the supplementation. The aim of this work was to explore long …

Differential apoptotic response of human cancer cells to organoselenium compounds

M Suzuki, M Endo, F Shinohara, S Echigo… - Cancer chemotherapy …, 2010 - Springer
Abstract Purpose Selenium (Se) compounds are well known to inhibit cell proliferation and
induce cell death in human cancer cells. Respective chemical forms of Se are intracellularly …

[HTML][HTML] Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy

R Liang, A Cheng, S Lu, X Zhang, M Ren… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Selenium (Se) is an essential trace element for biological processes. Seleno-amino acids
(Se-AAs), known as the organic forms of Se, and their metabolic reprogramming have been …