Objective To investigate the value of direct sequencing of sex-determining region Y (SRY)
gene, as well as peripheral blood karyotype analysis, in the diagnosis of disorders of sex …

BACKGROUND: The SRY gene encodes for a testis-specific transcription factor (TDF, testis
determining factor) that plays a key role in sexual differentiation and development in males …

Primed in situ labeling (PRINS) can be used to localize DNA segments too small to be
detected by fluorescence in situ hybridization. By PRINS we identified the SRY gene in two …

Materials and Methods High-molecular weight DNA was extracted from 15 mL of amniotic
fluid, using the Promega Wizard Genomic DNA Purification Kit (Madison, WI, USA). A …

Background SRY (sex-determining region, Y) is the gene responsible of gonadal
differentiation in the male and it is essential for the regular development of male genitalia …

The SRY gene on the short arm of the Y chromosome is necessary for male development.
Without SRY, patients with 46, XY karyotype develop as females, fail to achieve normal …

Sex reversal syndrome is a kind of human genetic disease about gender dysplasia, which is
characterised by inconsistency between gonadal sexuality and chromosome sexuality; the …

In mammals, a master gene located on the Y chromosome, the testis-determining gene SRY,
controls sex determination. SRY protein is expressed in the genital ridge before testis …

The first and essential step in normal sexual differentiation takes place during the 5th-6th
week of gestation. The testis determining factor (TDF) directs the undifferentiated gonad into …

PURPOSE: The pathogenesis of 46 XX true hermaphroditism is uncertain and the role of the
SRY gene in ovotestis development has not been thoroughly evaluated. We ascertained the …