Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the
coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two …

Nanoparticles (NPs) have demonstrated great potential for the oral delivery of protein drugs
that have very limited oral bioavailability. Orally administered NPs could be absorbed by the …

For enhanced oral insulin delivery, a strategy of acid-resistant and enteric hydrogels
encapsulating insulin-loaded nanoparticles was developed. The nanoparticles were …

Although nanoparticles (NPs) have been used for many drug delivery applications, oral
absorption of NPs has remained a big challenge. NPs for oral delivery of biotherapeutics …

The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …

Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …

Aim It was the aim of this study to combine two strategies–namely the virus-mimicking
strategy and the surface PEGylation strategy–in order to generate highly mucus permeating …

The oral delivery of macromolecules using nanoparticles is limited by secreted mucus,
resulting in low contact or internalization via intestinal cells and, thus, both mucus trapping …

Although significant progress has been achieved, effective oral delivery of protein drugs
such as insulin by nanoparticle-based carrier systems still faces certain formidable …

Oral administration is an ideal alternative for drug delivery due to its convenience and safety.
However, oral protein delivery is limited by biological barriers such as the mucus barrier and …