Oral delivery of protein drugs is an attractive route of administration due to its convenience
for repeated dosing and good patient compliance. However, currently oral protein …

Aims: The present study reports a novel approach for enhancing the oral absorption and
hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled polyethylene glycol …

The intestinal mucus gel layer represents a stumbling block for drug adsorption. This study is
aimed to formulate a nanoparticulate system able to overcome this barrier by cleaving …

The GI mucus layer represents a significant block to drug carriers absorption. Taking an
example from nature, virus-mimicking nanoparticles (NPs) with highly densely charged …

Although nanotechnology has been investigated during recent years to increase the
bioavailability and therapeutic effects of mucosal administrated drugs, numerous barriers …

Liver is the primary acting site of insulin. In this study, we developed innovative
nanoparticles for oral and liver-targeted delivery of insulin by using enterohepatic circulation …

Nanobiomaterials such as enveloped virus-like particles with specificity can serve a dual
function of vaccination and drug delivery system. Here, we expressed colon carcinoma cell …

The efficient delivery of antitumor agents to tumor sites faces numerous obstacles, such as
poor cellular uptake and slow intracellular drug release. In this regard, smart nanoparticles …

Orally administered targeted nanoparticles have a large number of potential biomedical
applications and display several putative advantages for oral drug delivery, such as the …

Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million
people across the world. An artificial “closed-loop” system able to mimic pancreas activity …