Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Objective Therapeutic failure of antibiotic therapy has been ascribed to pharmacokinetic
alterations in compromised patient populations. The present study, therefore, aimed at …

Objective To explore the effects of renal function estimated by measured creatinine
clearance (Cl CR) on trough serum concentration (C min) of piperacillin given to critically ill …

Sir, The combination of piperacillin and tazobactam has been shown to be efficacious for the
treatment of intra-abdominal infections, skin and soft tissue infections, bacteraemia and …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

Worldwide incidence of obesity is increasing and impaired outcome in postoperative
patients has been described. Antibiotic prescribing is complicated by different pharmacology …

This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU),
with an average age of 69 years, without neurologic disorder before initiation of a …