WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Despite the clinical use of piperacillin
for more than two decades, there are still contradictory reports whether or not the elimination …

We conducted a prospective study to determine whether predicted aminoglycoside
pharmacokinetic parameters (based on population averages) correlate with measured …

Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Optimization of antibiotic dosing is a treatment intervention that is likely to improve outcomes
in severe infections. The aim of this retrospective study was to describe the therapeutic …

Background: Antimicrobial pharmacokinetic and pharmacodynamic data are limited in
obesity. Objective: To evaluate the steady-state pharmacokinetics and pharmacodynamics …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

Objective: Doripenem is a valuable broad-spectrum antibiotic for empirical therapy in
critically ill patients, although little data exist to guide effective dosing. We sought to describe …

The aim of the present study was to evaluate the benefit of monitoring serum piperacillin
concentrations in critically ill patients. This was an 11-month, prospective, observational …

Background Controversies remain regarding optimal dosing and the need for plasma
concentration measurements when treating intensive care patients with beta‐lactam …

The pharmacokinetics of piperacillin were examined after single intravenous doses to three
groups of male patients with creatinine clearances of greater than or equal to 60 (group I) …