Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and
tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …

What is known and objective Obesity is a significant burden on the healthcare system in the
U nited S tates, and determining the appropriate antimicrobial dosing regimen in morbidly …

Background Amikacin is an aminoglycoside commonly used in intensive care units for the
treatment of patients with life-threatening Gram-negative infections. Although …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Background Critically ill patients often demonstrate extremely unusual volumes of
distribution (Vd) and half-lives (t1/2) of drugs. Imipenem is a widely used antibiotic in …

Aims To compare the pharmacokinetics of amoxicillin (AMX) in obese and nonobese
subjects, given as single dose 875‐mg tablets. Methods A prospective, single‐centre, open …

The pharmacokinetic parameters of amikacin were determined in a population of 20 adults
and 36 pediatric patients admitted into an intensive care unit. Amikacin was administered by …

Amikacin is commonly used for probabilistic antimicrobial therapy in critically ill patients with
sepsis. Its narrow therapeutic margin makes it challenging to determine the right individual …

The pharmacokinetics of a single 4 g intravenous bolus dose of piperacillin were
investigated in 5 normal subjects and 13 patients with moderate, severe or end-stage renal …