Severe sepsis is a major problem as cause of high rates morbidity and mortality in intensive
care units (ICU). Aminoglycosides are an important group of antimicrobials used for severe …

As obesity continues to increase in prevalence throughout the world, it becomes important to
explore the effects that obesity has on antimicrobial disposition. Physiologic changes in …

Sepsis continues to be a major cause of morbidity and mortality worldwide. In the United
States alone, sepsis accounts for 210,000 deaths annually, at a cost of $17 billion [1] …

OBJECTIVE: To compare the predictive performance of a Bayesian program incorporating a
population model with and without severity of illness covariates in intensive care unit (ICU) …

Studies have shown that critically ill patients display large variations in pharmacokinetics
mainly due to altered pathophysiology. An understanding of the pathophysiological changes …

Limited data exist for appropriate drug dosing in obese children. This comprehensive review
summarizes pharmacokinetic (PK) alterations that occur with age and obesity, and these …

The pharmacodynamics of dosage regimens of piperacillin alone or in combination with
tazobactam against piperacillin-resistant or-susceptible bacteria were studied in an in vitro …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Severe pathophysiological changes in critical illness can lead to dramatically altered
antimicrobial pharmacokinetics (PK). The additional effect of obesity on PK potentially …

The objective of the paper is to review the literature and provide recommendations for use of
aminoglycoside antibiotics in critically ill obese patients. Literature search in PubMed for all …