Effect of body mass index on treatment of complicated intra-abdominal infections in hospitalized adults: comparison of ertapenem with piperacillin-tazobactam
Background: Complicated intra-abdominal infections (cIAI) are a common problem in
surgical practice. The effect of body mass index (BMI) on the outcome is poorly understood …
surgical practice. The effect of body mass index (BMI) on the outcome is poorly understood …
Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator‐associated pneumonia and evaluation of dosage regimens
C Couffignal, O Pajot, C Laouénan… - British Journal of …, 2014 - Wiley Online Library
Aims Significant alterations in the pharmacokinetics (PK) of antimicrobials have been
reported in critically ill patients. We describe PK parameters of imipenem in intensive care …
reported in critically ill patients. We describe PK parameters of imipenem in intensive care …
Outcomes of extended-infusion piperacillin-tazobactam: a retrospective analysis of critically ill patients
GC Lee, H Liou, R Yee, CF Quan, K Neldner - Clinical therapeutics, 2012 - Elsevier
Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …
Piperacillin kinetics
VK Batra, JA Morrison, KC Lasseter… - Clinical Pharmacology …, 1979 - Wiley Online Library
Piperacillin was administered to normal, healthy volunteers by an intravenous infusion over
30 min at dosage regimens of 12 gm daily (4 gm every 8 hr) and 24 gm daily (6 gm every 6 …
30 min at dosage regimens of 12 gm daily (4 gm every 8 hr) and 24 gm daily (6 gm every 6 …
Influence of clinical diagnosis in the population pharmacokinetics of amikacin in intensive care unit patients
S Romano, M del Mar Fdez. de Gatta, V Calvo… - Clinical drug …, 1998 - Springer
The aim of the present study was to analyse the pharmacokinetic behaviour of amikacin in
intensive care unit (ICU) patients using a mixed-effect model and sparse data collected …
intensive care unit (ICU) patients using a mixed-effect model and sparse data collected …
Comparing clinical outcomes of piperacillin-tazobactam administration and dosage strategies in critically ill adult patients: a systematic review and meta-analysis
S Fawaz, S Barton, S Nabhani-Gebara - BMC Infectious Diseases, 2020 - Springer
Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …
proposed as a valuable alternative to traditional intermittent administration especially in …
Continuous infusion of piperacillin/tazobactam in septic critically ill patients—a multicenter propensity matched analysis
J Gonçalves-Pereira, BS Oliveira, S Janeiro, J Estilita… - PLoS …, 2012 - journals.plos.org
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients
with microbiologically documented infections is currently unknown. We conducted a …
with microbiologically documented infections is currently unknown. We conducted a …
Higher than standard dosing regimen are needed to achieve optimal antibiotic exposure in critically ill patients with augmented renal clearance receiving piperacillin …
C Carrie, R Legeron, L Petit, J Ollivier, V Cottenceau… - Journal of critical …, 2018 - Elsevier
Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …
Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia
Objectives: To determine the steady-state serum and alveolar concentrations of piperacillin/
tazobactam administered in continuous infusion to critically ill patients with ventilator …
tazobactam administered in continuous infusion to critically ill patients with ventilator …
Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients
C Roger, MO Cotta, L Muller, SC Wallis… - International Journal of …, 2017 - Elsevier
This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …
tazobactam administered as a 24-h continuous infusion between continuous venovenous …