[HTML][HTML] Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity

AK Anam, KM Cooke, MB Dratver, JV O'Bryan… - Molecular …, 2022 - Elsevier
Objective Maternal obesity increases the incidence of excess adiposity in newborns,
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …

Maternal obesity modulates intracellular lipid turnover in the human term placenta

B Hirschmugl, G Desoye, P Catalano… - International journal of …, 2017 - nature.com
Background: Obesity before pregnancy is associated with impaired metabolic status of the
mother and the offspring later in life. These adverse effects have been attributed to …

Effect of maternal obesity on placental lipid metabolism

V Calabuig-Navarro, M Haghiac, J Minium… - …, 2017 - academic.oup.com
Obese women, on average, give birth to babies with high fat mass. Placental lipid
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …

[HTML][HTML] Effects of maternal obesity on placental function and fetal development

KR Howell, TL Powell - Reproduction (Cambridge, England), 2017 - ncbi.nlm.nih.gov
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Role of insulin in placental transport of nutrients in gestational diabetes mellitus

M Ruiz-Palacios, AJ Ruiz-Alcaraz… - Annals of Nutrition and …, 2017 - karger.com
Background: Gestational diabetes mellitus (GDM) is associated with increased fetal
adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin …

Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment

F Delhaes, SA Giza, T Koreman, G Eastabrook… - Placenta, 2018 - Elsevier
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated
with pregnancy complications such as preeclampsia and gestational diabetes, and offspring …

Placental fatty acid transport in maternal obesity

I Cetin, F Parisi, C Berti, C Mandò… - Journal of developmental …, 2012 - cambridge.org
Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal
obesity is associated with a specific proinflammatory, endocrine and metabolic phenotype …

[HTML][HTML] Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner

A Kelly, J Chan, TL Powell, LA Cox… - Frontiers in Cell and …, 2023 - frontiersin.org
Infants born to obese mothers have an increased risk of developing obesity and metabolic
disease in childhood and adulthood. Although the molecular mechanisms linking maternal …

Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus

T Radaelli, J Lepercq, A Varastehpour, S Basu… - American journal of …, 2009 - Elsevier
OBJECTIVE: Changes in metabolic homeostasis in pregnant diabetic women are potential
determinants of increased adiposity of the fetus. The aim of this study was to characterize …