The analysis of readily available sputum samples from long-term chronic Pseudomonas
aeruginosa infections in the cystic fibrosis (CF) lung has provided unique insights into the …

Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Selective forces in the environment drive bacterial adaptation to novel niches, choosing the
fitter variants in the population. However, in dynamic and changing environments, the …

Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …

Rationale: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Cystic fibrosis (CF), the most common autosomal recessive disorder in Caucasians, and
chronic obstructive pulmonary disease (COPD), a disease of adults, are characterized by …

Individuals with cystic fibrosis (CF) suffer from frequent and recurring microbial airway
infections. The Gram-negative bacterium Pseudomonas aeruginosa is one of the most …

The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …