Simple Summary The epigenome is dynamic and flexible and can influence its phenotype
by turning the genes on and off based on the environment to which it is exposed. Significant …

Understanding the role of biased G protein-coupled receptor (GPCR) agonism in receptor
signaling may provide novel insights into the opposing effects mediated by cannabinoids …

Simple Summary In this study we investigated the role of cannabinoid receptor 2 (CB2R) on
immune cells in melanoma and found significantly improved overall survival in patients with …

Background: We previously reported that cannabidiol (CBD), a cannabinoid with a low
toxicity profile, downregulated the expression of the prometastatic gene inhibitor of DNA …

The endocannabinoid system (ECS) is a widely recognized lipid messenger system
involved in many aspects of our health and diseases. The system consists of cannabinoid …

Introduction: Recent studies have shown that the endocannabinoid system (ECS) could offer
an attractive antitumor target. Numerous findings suggest the involvement of this system …

The family of chemical structures that interact with a cannabinoid receptor are broadly
termed cannabinoids. Traditionally known for their psychotropic effects and their use as …

that the cellular, biochemical and behavioral responses to marijuana use are encoded in our
genes [3, 4]. Much of this progress in cannabi noid genomics is providing genetic variants …

The endocannabinoid system comprises the G-protein coupled CB1 cannabinoid receptor
(CB1R) and CB2 cannabinoid receptor (CB2R), their endogenous ligands …

The endocannabinoid system (ECS) employs a huge network of molecules (receptors,
ligands, and enzymatic machinery molecules) whose interactions with other cellular …