Immunological tolerance has evolved to curtail immune responses against self-antigens and
prevent autoimmunity. One mechanism that contributes to immunological tolerance is the …

CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to
as immunosurveillance. However, multiple inhibitory mechanisms within the tumor …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

The tumor microenvironment (TME) may be best conceptualized as an ecosystem
comprised of cancer cells interacting with a multitude of stromal components such as the …

Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

Persistent T cell antigen receptor (TCR) signaling by CD8 T cells is a feature of cancer and
chronic infections and results in the sustained expression of, and signaling by, inhibitory …

Cancer is the second leading cause of mortality worldwide. Despite recent advances in
cancer treatment including immunotherapy with immune checkpoint inhibitors, new …

Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic
acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on …

Lysophosphatidic acid (LPA) is a bioactive lipid enriched in the tumor microenvironment of
immunosuppressive malignancies such as ovarian cancer. Although LPA enhances the …

The tumor microenvironment (TME) consists of cancer cells that interact with stromal
components such as the extracellular matrix, blood, and lymphatic networks, fibroblasts …