With increasing age, the ability of the immune system to protect against new antigenic
challenges or to control chronic infections erodes. Decline in thymic function and cumulating …

T cell responses are altered in the aged in a manner usually interpreted as detrimental to
host defences against infectious agents and possibly also against cancer. T cell …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

The function of the immune system is to maintain body integrity by defending against
infections, cancers, autoimmune diseases and inflammation-related chronic diseases. The …

Aging of the immune system, or" immunosenescence," is associated with both a marked
reduction in responsiveness as well as functional dysregulation. These changes have been …