PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is
the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies …

Background Cascade genetic testing for hereditary cancer syndromes offers affected
relatives the opportunity to pursue cancer screening and risk‐reducing surgery and thus …

In cascade testing, genetic testing for an identified familial pathogenic variant extends to
disease-free relatives to allow genetically targeted disease prevention. We evaluated the …

Current guidelines recommend single variant testing in relatives of patients with known
pathogenic or likely pathogenic germline variants in cancer predisposition genes. This …

Cascade testing for cancer predisposition offers a highly efficient and cost-effective method
for identifying individuals at increased risk for cancer, in whom targeted interventions can …

PURPOSE Despite advances in DNA sequencing technology and expanded medical
guidelines, the vast majority of individuals carrying pathogenic variants of common cancer …

Next-generation sequencing genetic testing panels for cancer susceptibility (cancer panels)
have recently become clinically available. At present, clinical utility is unknown and there are …

PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

The advent of massively parallel (next-generation) sequencing presents a tremendous
opportunity for clinical cancer genetics. The ability to affordably sequence many (or even all) …

Approximately 5%-10% of all cancer is due to hereditary causes. Over the last 2 decades,
the ability to detect genes responsible for hereditary cancers has dramatically improved, and …